論文業績

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2020年 論文業績


 

 

 

 

 

一覧
  1. Asakura K, Kadota T, Matsuzaki J, Yoshida Y, Yamamoto Y, Nakagawa K, Takizawa S, Aoki Y, Nakamura E, Miura J, Sakamoto H, Kato K, Watanabe SI, Ochiya T. A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy. Commun Biol. 2020 Mar 19;3(1):134. doi: 10.1038/s42003-020-0863-y.PubMed PMID: 32193503; PubMed Central PMCID: PMC7081195.
  2. Kumazaki M, Shimomura I, Kiyono T, Ochiya T, Yamamoto Y. Cell-type specific tumorigenesis with Ras oncogenes in human lung epithelial cells. Biochem Biophys Res Commun. 2020 Feb 25. pii: S0006-291X(20)30394-6. doi:10.1016/j.bbrc.2020.02.113. [Epub ahead of print] PubMed PMID: 32111352.
  3. Nishida-Aoki N, Tominaga N, Kosaka N, Ochiya T. Altered biodistribution of
    deglycosylated extracellular vesicles through enhanced cellular uptake. J
    Extracell Vesicles. 2020 Jan 13;9(1):1713527. doi: 10.1080/20013078.2020.1713527.
    eCollection 2020. PubMed PMID: 32082512; PubMed Central PMCID: PMC7006786.
  4. Nishida-Aoki N, Izumi Y, Takeda H, Takahashi M, Ochiya T, Bamba T. Lipidomic
    Analysis of Cells and Extracellular Vesicles from High- and Low-Metastatic
    Triple-Negative Breast Cancer. Metabolites. 2020 Feb 13;10(2). pii: E67. doi:
    10.3390/metabo10020067. PubMed PMID: 32069969.
  5. Yamamoto Y, Kondo S, Matsuzaki J, Esaki M, Okusaka T, Shimada K, Murakami Y,
    Enomoto M, Tamori A, Kato K, Aoki Y, Takizawa S, Sakamoto H, Niida S, Takeshita
    F, Ochiya T. Highly Sensitive Circulating MicroRNA Panel for Accurate Detection
    of Hepatocellular Carcinoma in Patients With Liver Disease. Hepatol Commun. 2019
    Dec 19;4(2):284-297. doi: 10.1002/hep4.1451. eCollection 2020 Feb. PubMed PMID:
    32025611; PubMed Central PMCID: PMC6996324.
  6. Noda-Narita S, Shimomura A, Tanabe Y, Kawauchi J, Matsuzaki J, Takizawa S,
    Aoki Y, Shimizu C, Tamura K, Ochiya T. Peripheral neuropathy from paclitaxel:
    risk prediction by serum microRNAs. BMJ Support Palliat Care. 2020 Jan 14. pii:
    bmjspcare-2019-001900. doi: 10.1136/bmjspcare-2019-001900. [Epub ahead of print]
    PubMed PMID: 31937590.
  7. Urabe F, Kosaka N, Ito K, Kimura T, Egawa S, Ochiya T. Extracellular vesicles
    as biomarkers and therapeutic targets for cancer. Am J Physiol Cell Physiol. 2020
    Jan 1;318(1):C29-C39. doi: 10.1152/ajpcell.00280.2019. Epub 2019 Nov 6. PubMed
    PMID: 31693397.
  8. Katsuda T, Hosaka K, Matsuzaki J, Usuba W, Prieto-Vila M, Yamaguchi T,
    Tsuchiya A, Terai S, Ochiya T. Transcriptomic Dissection of Hepatocyte
    Heterogeneity: Linking Ploidy, Zonation, and Stem/Progenitor Cell
    Characteristics. Cell Mol Gastroenterol Hepatol. 2020;9(1):161-183. doi:
    10.1016/j.jcmgh.2019.08.011. Epub 2019 Sep 5. PubMed PMID: 31493546; PubMed
    Central PMCID: PMC6909008.
  9. Katsuda T, Kawamata M, Inoue A, Yamaguchi T, Abe M, Ochiya T. Long-term
    maintenance of functional primary human hepatocytes using small molecules. FEBS
    Lett. 2020 Jan;594(1):114-125. doi: 10.1002/1873-3468.13582. Epub 2019 Aug 30.
    PubMed PMID: 31432507.

2019年 論文業績


一覧
  1. Yasukawa K, Liew LC, Hagiwara K, Hironaka-Mitsuhashi A, Qin XY, Furutani Y,
    Tanaka Y, Nakagama H, Kojima S, Kato T, Ochiya T, Gailhouste L.
    MicroRNA-493-5p-mediated repression of the MYCN oncogene inhibits hepatic cancer
    cell growth and invasion. Cancer Sci. 2019 Dec 27. doi: 10.1111/cas.14292. [Epub
    ahead of print] PubMed PMID: 31883160.
  2. Shimomura A, Ochiya T. [Ⅰ.Detecting Early Breast Cancer by Serum MicroRNA].
    Gan To Kagaku Ryoho. 2019 Dec;46(12):1837-1840. Japanese. PubMed PMID: 31879399.
  3. Hironaka-Mitsuhashi A, Otsuka K, Gailhouste L, Sanchez Calle A, Kumazaki M,
    Yamamoto Y, Fujiwara Y, Ochiya T. MiR-1285-5p/TMEM194A axis affects cell
    proliferation in breast cancer. Cancer Sci. 2019 Dec 18. doi: 10.1111/cas.14287.
    [Epub ahead of print] PubMed PMID: 31854049.
  4. Liew LC, Gailhouste L, Tan GC, Yamamoto Y, Takeshita F, Nakagama H, Ochiya T.
    MicroRNA-124a inhibits endoderm lineage commitment by targeting Sox17 and Gata6
    in mouse embryonic stem cells. Stem Cells. 2019 Dec 11. doi: 10.1002/stem.3136.
    [Epub ahead of print] PubMed PMID: 31828873.
  5. Ohno M, Matsuzaki J, Kawauchi J, Aoki Y, Miura J, Takizawa S, Kato K,
    Sakamoto H, Matsushita Y, Takahashi M, Miyakita Y, Ichimura K, Narita Y, Ochiya
    T. Assessment of the Diagnostic Utility of Serum MicroRNA Classification in
    Patients With Diffuse Glioma. JAMA Netw Open. 2019 Dec 2;2(12):e1916953. doi:
    10.1001/jamanetworkopen.2019.16953. PubMed PMID: 31808923.
  6. Urabe F, Kosaka N, Ito K, Kimura T, Egawa S, Ochiya T. Extracellular vesicles
    as biomarkers and therapeutic targets for cancer. Am J Physiol Cell Physiol. 2019
    Nov 6. doi: 10.1152/ajpcell.00280.2019. [Epub ahead of print] PubMed PMID:
    31693397.
  7. Itami-Matsumoto S, Hayakawa M, Uchida-Kobayashi S, Enomoto M, Tamori A,
    Mizuno K, Toyoda H, Tamura T, Akutsu T, Ochiya T, Kawada N, Murakami Y.
    Circulating Exosomal miRNA Profiles Predict the Occurrence and Recurrence of
    Hepatocellular Carcinoma in Patients with Direct-Acting Antiviral-Induced
    Sustained Viral Response. Biomedicines. 2019 Nov 3;7(4). pii: E87. doi:
    10.3390/biomedicines7040087. PubMed PMID: 31684167.
  8. Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Sakurai
    T, Ozaki K, Ochiya T, Niida S. A comparison of machine learning classifiers for
    dementia with Lewy bodies using miRNA expression data. BMC Med Genomics. 2019 Oct
    30;12(1):150. doi: 10.1186/s12920-019-0607-3. PubMed PMID: 31666070; PubMed
    Central PMCID: PMC6822471.
  9. Sudo K, Kato K, Matsuzaki J, Takizawa S, Aoki Y, Shoji H, Iwasa S, Honma Y,
    Takashima A, Sakamoto H, Naka T, Sekine S, Boku N, Ochiya T. Identification of
    serum microRNAs predicting the response of esophageal squamous-cell carcinoma to
    nivolumab. Jpn J Clin Oncol. 2019 Oct 15. pii: hyz146. doi: 10.1093/jjco/hyz146.
    [Epub ahead of print] PubMed PMID: 31612917.
  10. Sato J, Shimomura A, Kawauchi J, Matsuzaki J, Yamamoto Y, Takizawa S,
    Sakamoto H, Ohno M, Narita Y, Ochiya T, Tamura K. Brain metastasis-related
    microRNAs in patients with advanced breast cancer. PLoS One. 2019 Oct
    11;14(10):e0221538. doi: 10.1371/journal.pone.0221538. eCollection 2019. PubMed
    PMID: 31603918; PubMed Central PMCID: PMC6788729.
  11. Yokoi A, Matsuzaki J, Yamamoto Y, Tate K, Yoneoka Y, Shimizu H, Uehara T,
    Ishikawa M, Takizawa S, Aoki Y, Kato K, Kato T, Ochiya T. Serum microRNA profile
    enables preoperative diagnosis of uterine leiomyosarcoma. Cancer Sci. 2019
    Dec;110(12):3718-3726. doi: 10.1111/cas.14215. Epub 2019 Nov 16. PubMed PMID:
    31599471.
  12. Huang Y, Sakai Y, Hara T, Katsuda T, Ochiya T, Adachi T, Hidaka M, Gu WL,
    Eguchi S. Development of Bifunctional Three-Dimensional Cysts from Chemically
    Induced Liver Progenitors. Stem Cells Int. 2019 Sep 3;2019:3975689. doi:
    10.1155/2019/3975689. eCollection 2019. PubMed PMID: 31565060; PubMed Central
    PMCID: PMC6745155.
  13. Jang SC, Crescitelli R, Cvjetkovic A, Belgrano V, Olofsson Bagge R, Sundfeldt
    K, Ochiya T, Kalluri R, Lötvall J. Mitochondrial protein enriched extracellular
    vesicles discovered in human melanoma tissues can be detected in patient plasma.
    J Extracell Vesicles. 2019 Aug 27;8(1):1635420. doi:
    10.1080/20013078.2019.1635420. eCollection 2019. PubMed PMID: 31497264; PubMed
    Central PMCID: PMC6719261.
  14. Katsuda T, Hosaka K, Matsuzaki J, Usuba W, Prieto-Vila M, Yamaguchi T,
    Tsuchiya A, Terai S, Ochiya T. Transcriptomic Dissection of Hepatocyte
    Heterogeneity: Linking Ploidy, Zonation, and Stem/Progenitor Cell
    Characteristics. Cell Mol Gastroenterol Hepatol. 2019 Sep 5;9(1):161-183. doi:
    10.1016/j.jcmgh.2019.08.011. [Epub ahead of print] PubMed PMID: 31493546.
  15. Satomi-Tsushita N, Shimomura A, Matsuzaki J, Yamamoto Y, Kawauchi J, Takizawa
    S, Aoki Y, Sakamoto H, Kato K, Shimizu C, Ochiya T, Tamura K. Serum
    microRNA-based prediction of responsiveness to eribulin in metastatic breast
    cancer. PLoS One. 2019 Sep 4;14(9):e0222024. doi: 10.1371/journal.pone.0222024.
    eCollection 2019. PubMed PMID: 31483849; PubMed Central PMCID: PMC6726239.
  16. Hironaka-Mitsuhashi A, Sanchez Calle A, Ochiya T, Takayama S, Suto A. Towards
    Circulating-Tumor DNA-Based Precision Medicine. J Clin Med. 2019 Sep 2;8(9). pii:
    E1365. doi: 10.3390/jcm8091365. Review. PubMed PMID: 31480647; PubMed Central
    PMCID: PMC6780195.
  17. Konno M, Koseki J, Asai A, Yamagata A, Shimamura T, Motooka D, Okuzaki D,
    Kawamoto K, Mizushima T, Eguchi H, Takiguchi S, Satoh T, Mimori K, Ochiya T, Doki
    Y, Ofusa K, Mori M, Ishii H. Distinct methylation levels of mature microRNAs in
    gastrointestinal cancers. Nat Commun. 2019 Aug 29;10(1):3888. doi:
    10.1038/s41467-019-11826-1. PubMed PMID: 31467274; PubMed Central PMCID:
    PMC6715669.
  18. Kawamura Y, Sanchez Calle A, Yamamoto Y, Sato TA, Ochiya T. Extracellular
    vesicles mediate the horizontal transfer of an active LINE-1 retrotransposon. J
    Extracell Vesicles. 2019 Jul 23;8(1):1643214. doi: 10.1080/20013078.2019.1643214.
    eCollection 2019. PubMed PMID: 31448067; PubMed Central PMCID: PMC6691892.
  19. Yamamoto T, Kosaka N, Ochiya T. Latest advances in extracellular vesicles:
    from bench to bedside. Sci Technol Adv Mater. 2019 Jun 17;20(1):746-757. doi:
    10.1080/14686996.2019.1629835. eCollection 2019. Review. PubMed PMID: 31447954;
    PubMed Central PMCID: PMC6691912.
  20. Katsuda T, Kawamata M, Inoue A, Yamaguchi T, Abe M, Ochiya T. Long-term
    maintenance of functional primary human hepatocytes using small molecules. FEBS
    Lett. 2019 Aug 21. doi: 10.1002/1873-3468.13582. [Epub ahead of print] PubMed
    PMID: 31432507.
  21. Katsuda T, Matsuzaki J, Yamaguchi T, Yamada Y, Prieto-Vila M, Hosaka K,
    Takeuchi A, Saito Y, Ochiya T. Generation of human hepatic progenitor cells with
    regenerative and metabolic capacities from primary hepatocytes. Elife. 2019 Aug
    8;8. pii: e47313. doi: 10.7554/eLife.47313. [Epub ahead of print] PubMed PMID:
    31393263.
  22. Zhou Y, Yamamoto Y, Xiao Z, Ochiya T. The Immunomodulatory Functions of
    Mesenchymal Stromal/Stem Cells Mediated via Paracrine Activity. J Clin Med. 2019
    Jul 12;8(7). pii: E1025. doi: 10.3390/jcm8071025. Review. PubMed PMID: 31336889;
    PubMed Central PMCID: PMC6678920.
  23. Gailhouste L, Liew LC, Yasukawa K, Hatada I, Tanaka Y, Kato T, Nakagama H,
    Ochiya T. MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483
    loss of imprinting in hepatic cancer cells. Cell Death Dis. 2019 Jul
    18;10(8):553. doi: 10.1038/s41419-019-1788-6. PubMed PMID: 31320614; PubMed
    Central PMCID: PMC6639415.
  24. Yamaguchi T, Matsuzaki J, Katsuda T, Saito Y, Saito H, Ochiya T. Generation of
    functional human hepatocytes in vitro: current status and future prospects.
    Inflamm Regen. 2019 Jul 2;39:13. doi: 10.1186/s41232-019-0102-4. eCollection
    2019. Review. PubMed PMID: 31308858; PubMed Central PMCID: PMC6604181.
  25. Prieto-Vila M, Usuba W, Takahashi RU, Shimomura I, Sasaki H, Ochiya T,
    Yamamoto Y. Single-cell Analysis Reveals a Preexisting Drug-Resistant
    Subpopulation in the Luminal Breast Cancer Subtype. Cancer Res. 2019 Jul 9. pii:
    canres.0122.2019. doi: 10.1158/0008-5472.CAN-19-0122. [Epub ahead of print]
    PubMed PMID: 31289135.
  26. Kamiya A, Hayama Y, Kato S, Shimomura A, Shimomura T, Irie K, Kaneko R,
    Yanagawa Y, Kobayashi K, Ochiya T. Genetic manipulation of autonomic nerve fiber
    innervation and activity and its effect on breast cancer progression. Nat
    Neurosci. 2019 Jul 8. doi: 10.1038/s41593-019-0430-3. [Epub ahead of print]
    PubMed PMID: 31285612.
  27. Clayton A, Buschmann D, Byrd JB, Carter DRF, Cheng L, Compton C, Daaboul G,
    Devitt A, Falcon-Perez JM, Gardiner C, Gustafson D, Harrison P, Helmbrecht C,
    Hendrix A, Hill A, Hoffman A, Jones JC, Kalluri R, Kang JY, Kirchner B, Lässer C,
    Lawson C, Lenassi M, Levin C, Llorente A, Martens-Uzunova ES, Möller A, Musante
    L, Ochiya T, Pink RC, Tahara H, Wauben MHM, Webber JP, Welsh JA, Witwer KW, Yin
    H, Nieuwland R. Summary of the ISEV workshop on extracellular vesicles as disease
    biomarkers, held in Birmingham, UK, during December 2017. J Extracell Vesicles.
    2018 May 17;7(1):1473707. doi: 10.1080/20013078.2018.1473707. eCollection 2018.
    PubMed PMID: 31162490; PubMed Central PMCID: PMC5965025.
  28. Naito Y, Yamamoto Y, Sakamoto N, Shimomura I, Kogure A, Kumazaki M, Yokoi A,
    Yashiro M, Kiyono T, Yanagihara K, Takahashi RU, Hirakawa K, Yasui W, Ochiya T.
    Cancer extracellular vesicles contribute to stromal heterogeneity by inducing
    chemokines in cancer-associated fibroblasts. Oncogene. 2019 Jul;38(28):5566-5579.
    doi: 10.1038/s41388-019-0832-4. Epub 2019 May 30. PubMed PMID: 31147602.
  29. Sonoda T, Matsuzaki J, Yamamoto Y, Sakurai T, Aoki Y, Takizawa S, Niida S,
    Ochiya T. Serum MicroRNA-Based Risk Prediction for Stroke. Stroke. 2019
    Jun;50(6):1510-1518. doi: 10.1161/STROKEAHA.118.023648. Epub 2019 Apr 15. PubMed
    PMID: 31136284.
  30. Kikuchi S, Yoshioka Y, Prieto-Vila M, Ochiya T. Involvement of Extracellular
    Vesicles in Vascular-Related Functions in Cancer Progression and Metastasis. Int
    J Mol Sci. 2019 May 26;20(10). pii: E2584. doi: 10.3390/ijms20102584. Review.
    PubMed PMID: 31130715; PubMed Central PMCID: PMC6566766.
  31. Sudo K, Kato K, Matsuzaki J, Boku N, Abe S, Saito Y, Daiko H, Takizawa S, Aoki
    Y, Sakamoto H, Niida S, Takeshita F, Fukuda T, Ochiya T. Development and
    Validation of an Esophageal Squamous Cell Carcinoma Detection Model by
    Large-Scale MicroRNA Profiling. JAMA Netw Open. 2019 May 3;2(5):e194573. doi:
    10.1001/jamanetworkopen.2019.4573. PubMed PMID: 31125107.
  32. Akazawa Y, Mizuno S, Fujinami N, Suzuki T, Yoshioka Y, Ochiya T, Nakamoto Y, Nakatsura T. Usefulness of serum microRNA as a predictive marker of recurrence and prognosis in biliary tract cancer after radical surgery. Sci Rep. 2019 Apr 11;9(1):5925. doi: 10.1038/s41598-019-42392-7. PubMed PMID: 30976046.
  33. Kohama I, Kosaka N, Chikuda H, Ochiya T. An Insight into the Roles of
    MicroRNAs and Exosomes in Sarcoma. Cancers (Basel). 2019 Mar 26;11(3). pii: E428. doi: 10.3390/cancers11030428. Review. PubMed PMID: 30917542.
  34. Urabe F, Ochiya T, Egawa S. Re: A Prospective Adaptive Utility Trial to
    Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2-10ng/ml at Initial Biopsy. Eur Urol. 2019 Mar 21. pii: S0302-2838(19)30183-6. doi: 10.1016/j.eururo.2019.02.036. [Epub ahead of print] PubMed PMID: 30905514.
  35. Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T. A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes. Nat Commun. 2019  Mar 21;10(1):1299. doi: 10.1038/s41467-019-09143-8. PubMed PMID: 30898996; PubMed Central PMCID: PMC6428849.
  36. Kosaka N, Kogure A, Yamamoto T, Urabe F, Usuba W, Prieto-Vila M, Ochiya T. Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications. Exp Mol Med. 2019 Mar 15;51(3):31. doi: 10.1038/s12276-019-0219-1. Review. PubMed PMID: 30872565; PubMed Central PMCID: PMC6418231.
  37. Shimomura I, Yamamoto Y, Ochiya T. Synthetic Lethality in Lung Cancer-From the Perspective of Cancer Genomics. Medicines (Basel). 2019 Mar 12;6(1). pii: E38. doi: 10.3390/medicines6010038. Review. PubMed PMID: 30871030.
  38. Shimomura I, Yokoi A, Kohama I, Kumazaki M, Tada Y, Tatsumi K, Ochiya T, Yamamoto Y. Drug library screen reveals benzimidazole derivatives as selective cytotoxic agents for KRAS-mutant lung cancer. Cancer Lett. 2019 Jun 1;451:11-22.  doi: 10.1016/j.canlet.2019.03.002. Epub 2019 Mar 9. PubMed PMID: 30862488.
  39. Hamada-Tsutsumi S, Naito Y, Sato S, Takaoka A, Kawashima K, Isogawa M, Ochiya T, Tanaka Y. The antiviral effects of human microRNA miR-302c-3p against hepatitis B virus infection. Aliment Pharmacol Ther. 2019 Apr;49(8):1060-1070. doi: 10.1111/apt.15197. Epub 2019 Mar 3. PubMed PMID: 30828831.
  40. Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S. Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data. Commun Biol. 2019 Feb 25;2:77. doi: 10.1038/s42003-019-0324-7. eCollection 2019. PubMed PMID: 30820472; PubMed Central PMCID: PMC6389908.
  41. Urabe F, Matsuzaki J, Yamamoto Y, Kimura T, Hara T, Ichikawa M, Takizawa S,Aoki Y, Niida S, Sakamoto H, Kato K, Egawa S, Fujimoto H, Ochiya T. Large-scale Circulating microRNA Profiling for the Liquid Biopsy of Prostate Cancer. Clin Cancer Res. 2019 Feb 26. doi: 10.1158/1078-0432.CCR-18-2849. [Epub ahead of print] PubMed PMID: 30808771.
  42. Takahashi RU, Prieto-Vila M, Kohama I, Ochiya T. Development of miRNA-based therapeutic approaches for cancer patients. Cancer Sci. 2019 Apr;110(4):1140-1147. doi: 10.1111/cas.13965. Epub 2019 Feb 26. Review. PubMed PMID: 30729639.
  43. Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD,Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C,
    Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP,
    Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D’Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G,
    Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H,
    Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ 2nd, Kornek M, Kosanović
    MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD,  Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Linē A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez  MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG Jr, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-‘t Hoen EN, Noren Hooten N, O’Driscoll L, O’Grady T, O’Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea
    X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL 2nd, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, Toxavidis V, Urbanelli L, Vader P, van Balkom BW, van der Grein SG, Van Deun J, van Herwijnen MJ, Van Keuren-Jensen K, van Niel G, van Royen ME, van Wijnen AJ, Vasconcelos MH, Vechetti IJ Jr, Veit TD, Vella LJ, Velot É, Verweij FJ, Vestad B,
    Viñas JL, Visnovitz T, Vukman KV, Wahlgren J, Watson DC, Wauben MH, Weaver A, Webber JP, Weber V, Wehman AM, Weiss DJ, Welsh JA, Wendt S, Wheelock AM, Wiener Z, Witte L, Wolfram J, Xagorari A, Xander P, Xu J, Yan X, Yáñez-Mó M, Yin H, Yuana Y, Zappulli V, Zarubova J, Žėkas V, Zhang JY, Zhao Z, Zheng L, Zheutlin AR,
    Zickler AM, Zimmermann P, Zivkovic AM, Zocco D, Zuba-Surma EK. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position
    statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750. eCollection 2018. PubMed PMID: 30637094; PubMed Central PMCID: PMC6322352.
  44. Kogure A, Kosaka N, Ochiya T. Cross-talk between cancer cells and their neighbors via miRNA in extracellular vesicles: an emerging player in cancer metastasis. J Biomed Sci. 2019 Jan 12;26(1):7. doi:10.1186/s12929-019-0500-6.
    Review. PubMed PMID: 30634952; PubMed Central PMCID: PMC6330499.
  45. Katsuda T, Ochiya T, Sakai Y. Generation of Hepatic Organoids with Biliary Structures. Methods Mol Biol. 2019;1905:175-185. doi:10.1007/978-1-4939-8961-4_16. PubMed PMID: 30536100.
  46. Katsuda T, Ochiya T. Chemically Induced Liver Progenitors (CLiPs): A Novel Cell Source for Hepatocytes and Biliary Epithelial Cells. Methods Mol Biol. 2019;1905:117-130. doi: 10.1007/978-1-4939-8961-4_11. PubMed PMID: 30536095.

2018年 論文業績


一覧
  1. Matsuzaki J, Ochiya T. Extracellular microRNAs and oxidative stress in liver injury: a systematic mini review. J Clin Biochem Nutr. 2018 Jul;63(1):6-11. doi: 10.3164/jcbn.17-123. Epub 2018 Apr 11. Review. PubMed PMID: 30087537; PubMed Central PMCID: PMC6064810.
  2. Yoshioka Y, Katsuda T, Ochiya T. Extracellular vesicles and encapusulated miRNAs as emerging cancer biomarkers for novel liquid biopsy. Jpn J Clin Oncol. 2018 Oct 1;48(10):869-876. doi: 10.1093/jjco/hyy120. Review. PubMed PMID: 30169666.
  3. Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K. UBL3 modification influences protein sorting to small extracellular vesicles.  Nat Commun. 2018 Sep 26;9(1):3936. doi: 10.1038/s41467-018-06197-y. PubMed PMID: 30258067; PubMed Central PMCID: PMC6158211.
  4. Fujita Y, Kadota T, Araya J, Ochiya T, Kuwano K. Clinical Application of Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapeutics for Inflammatory Lung Diseases. J Clin Med. 2018 Oct 14;7(10). pii: E355. doi: 10.3390/jcm7100355. Review. PubMed PMID: 30322213; PubMed Central PMCID: PMC6210470.
  5. Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T. Integrated extracellular microRNA profiling for ovarian cancer screening. Nat Commun. 2018 Oct 17;9(1):4319. doi:
    10.1038/s41467-018-06434-4. PubMed PMID: 30333487; PubMed Central PMCID: PMC6192980.
  6. Usuba W, Urabe F, Yamamoto Y, Matsuzaki J, Sasaki H, Ichikawa M, Takizawa S, Aoki Y, Niida S, Kato K, Egawa S, Chikaraishi T, Fujimoto H, Ochiya T. Circulating miRNA panels for specific and early detection in bladder cancer. Cancer Sci. 2019 Jan;110(1):408-419. doi: 10.1111/cas.13856. Epub 2018 Dec 12. PubMed PMID: 30382619; PubMed Central PMCID: PMC6317958.
  7. Shiozawa K, Yoshioka Y, Qiao Z, Shuting J, Ochiya T, Kondo T. Pazopanib-induced changes in protein expression signatures of extracellular vesicles in synovial sarcoma. Biochem Biophys Res Commun. 2018 Nov 30;506(3):723-730. doi: 10.1016/j.bbrc.2018.10.012. Epub 2018 Oct 27. PubMed PMID: 30454707.
  8. Kanda Y, Kawaguchi T, Osaki M, Onuma K, Ochiya T, Kitagawa T, Okada F. Fascin protein stabilization by miR-146a implicated in the process of a chronic inflammation-related colon carcinogenesis model. Inflamm Res. 2018 Jul 28. doi: 10.1007/s00011-018-1175-2. [Epub ahead of print] PubMed PMID: 30056535.
  9. Naito Y, Hamada-Tsutsumi S, Yamamoto Y, Kogure A, Yoshioka Y, Watashi K, Ochiya T, Tanaka Y. Screening of microRNAs for a repressor of hepatitis B virus replication. Oncotarget. 2018 Jul 6;9(52):29857-29868. doi: 10.18632/oncotarget.25557. eCollection 2018 Jul 6. PubMed PMID: 30042818; PubMed Central PMCID: PMC6057454.
  10. Gailhouste L, Liew LC, Yasukawa K, Hatada I, Tanaka Y, Nakagama H, Ochiya T.Differentiation Therapy by Epigenetic Reconditioning Exerts Antitumor Effects on Liver Cancer Cells. Mol Ther. 2018 Jul 5;26(7):1840-1854. doi: 10.1016/j.ymthe.2018.04.018. Epub 2018 Apr 26. PubMed PMID: 29759938; PubMed Central PMCID: PMC6035736.
  11. Sanchez Calle A, Kawamura Y, Yamamoto Y, Takeshita F, Ochiya T. Emerging roles of long non-coding RNA in cancer. Cancer Sci. 2018 Jul;109(7):2093-2100. doi: 10.1111/cas.13642. Epub 2018 Jun 28. Review. PubMed PMID: 29774630; PubMed Central PMCID: PMC6029823.
  12. Fujiwara Y, Saito M, Robles AI, Nishida M, Takeshita F, Watanabe M, Ochiya T, Yokota J, Kohno T, Harris CC, Tsuchiya N. A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network. EBioMedicine. 2018 Jul;33:33-48. doi: 10.1016/j.ebiom.2018.06.031. Epub 2018 Jul 7. PubMed PMID: 30049386; PubMed Central PMCID: PMC6085539.
  13. Matsuzaki J, Ochiya T. Extracellular microRNAs and oxidative stress in liver injury: a systematic mini review. J Clin Biochem Nutr. 2018 Jul;63(1):6-11. doi: 10.3164/jcbn.17-123. Epub 2018 Apr 11. Review. PubMed PMID: 30087537; PubMed Central PMCID: PMC6064810.
  14. Takahashi RU, Prieto-Vila M, Kohama I, Ochiya T. [MicroRNA in Body Fluids -Development of the Novel Plat Form for Cancer Therapeutics and Diagnosis]. Gan To Kagaku Ryoho. 2018 Jun;45(6):899-905. Japanese. PubMed PMID: 30026410.
  15. Urabe F, Kosaka N, Kimura T, Egawa S, Ochiya T. Extracellular vesicles: Toward a clinical application in urological cancer treatment. Int J Urol. 2018 Jun;25(6):533-543. doi: 10.1111/iju.13594. Epub 2018 May 3. Review. PubMed PMID: 29726046.
  16. Otsuka K, Yamamoto Y, Ochiya T. Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer. Oncotarget. 2018 May 15;9(37):24718-24730. doi: 10.18632/oncotarget.25339. eCollection 2018 May 15. PubMed PMID: 29872500; PubMed Central PMCID: PMC5973863.
  17. Miyazaki M, Otomo R, Matsushima-Hibiya Y, Suzuki H, Nakajima A, Abe N, Tomiyama A, Ichimura K, Matsuda K, Watanabe T, Ochiya T, Nakagama H, Sakai R, Enari M. The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas. Cell Death Discov. 2018 May 10;4:56. doi: 10.1038/s41420-018-0059-0. eCollection 2018. PubMed PMID: 29760954; PubMed Central PMCID: PMC5945735.
  18. Fujita Y, Kadota T, Araya J, Ochiya T, Kuwano K. Extracellular Vesicles: New Players in Lung Immunity. Am J Respir Cell Mol Biol. 2018 May;58(5):560-565. doi: 10.1165/rcmb.2017-0293TR. PubMed PMID: 29115853.
  19. Gailhouste L, Liew LC, Hatada I, Nakagama H, Ochiya T. Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells. Cell Death Dis. 2018 May 1;9(5):468. doi: 10.1038/s41419-018-0487-z. PubMed PMID: 29700299; PubMed Central PMCID: PMC5920091.
  20. Yukawa H, Suzuki K, Aoki K, Arimoto T, Yasui T, Kaji N, Ishikawa T, Ochiya T, Baba Y. Imaging of angiogenesis of human umbilical vein endothelial cells by uptake of exosomes secreted from hepatocellular carcinoma cells. Sci Rep. 2018 Apr 30;8(1):6765. doi: 10.1038/s41598-018-24563-0. PubMed PMID: 29713019; PubMed Central PMCID: PMC5928189.
  21. Kadota T, Fujita Y, Yoshioka Y, Araya J, Kuwano K, Ochiya T. Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases. Mol Aspects Med. 2018 Apr;60:92-103. doi: 10.1016/j.mam.2017.11.005. Epub 2017 Nov 20. Review. PubMed PMID: 29146100.
  22. Yamamoto T, Kosaka N, Hattori Y, Ochiya T. A Challenge to Aging Society by microRNA in Extracellular Vesicles: microRNA in Extracellular Vesicles as Promising Biomarkers and Novel Therapeutic Targets in Multiple Myeloma. J Clin Med. 2018 Mar 12;7(3). pii: E55. doi: 10.3390/jcm7030055. Review. PubMed PMID: 29534557; PubMed Central PMCID: PMC5867581.
  23. Shimagaki T, Yoshizumi T, Harimoto N, Yoshio S, Naito Y, Yamamoto Y, Ochiya T, Yoshida Y, Kanto T, Maehara Y. MicroRNA-125b expression and intrahepatic metastasis are predictors for early recurrence after hepatocellular carcinoma resection. Hepatol Res. 2018 Mar;48(4):313-321. doi: 10.1111/hepr.12990. Epub 2017 Dec 5. PubMed PMID: 28984009.
  24. Hashimoto K, Ochi H, Sunamura S, Kosaka N, Mabuchi Y, Fukuda T, Yao K, Kanda H, Ae K, Okawa A, Akazawa C, Ochiya T, Futakuchi M, Takeda S, Sato S. Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2204-2209. doi: 10.1073/pnas.1717363115. Epub 2018 Feb 12. PubMed PMID: 29440427; PubMed Central PMCID: PMC5834702.
  25. Somiya M, Yoshioka Y, Ochiya T. Biocompatibility of highly purified bovine milk-derived extracellular vesicles. J Extracell Vesicles. 2018 Feb 21;7(1):1440132. doi: 10.1080/20013078.2018.1440132. eCollection 2018. PubMed PMID: 29511463; PubMed Central PMCID: PMC5827637.
  26. Yoshimura A, Adachi N, Matsuno H, Kawamata M, Yoshioka Y, Kikuchi H, Odaka H, Numakawa T, Kunugi H, Ochiya T, Tamai Y. The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles. Dis Model Mech. 2018 Jan 30;11(1). pii: dmm028779. doi: 10.1242/dmm.028779. PubMed PMID: 29208635; PubMed Central PMCID: PMC5818070.
  27. Miyazaki H, Takahashi RU, Prieto-Vila M, Kawamura Y, Kondo S, Shirota T, Ochiya T. CD44 exerts a functional role during EMT induction in cisplatin-resistant head and neck cancer cells. Oncotarget. 2018 Jan 13;9(11):10029-10041. doi: 10.18632/oncotarget.24252. eCollection 2018 Feb 9. PubMed PMID: 29515788; PubMed Central PMCID: PMC5839369.
  28. Shiozawa K, Shuting J, Yoshioka Y, Ochiya T, Kondo T. Extracellular vesicle-encapsulated microRNA-761 enhances pazopanib resistance in synovial sarcoma. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1322-1327. doi: 10.1016/j.bbrc.2017.11.164. Epub 2017 Nov 27. PubMed PMID: 29191657.
  29. Urabe F, Yoshioka Y, Ochiya T. [The biological role of exosomes in bone remodeling and bone diseases.]. Clin Calcium. 2018;28(1):122-127. doi: CliCa1801122127. Japanese. PubMed PMID: 29279437.
  30. Otsuka K, Yamamoto Y, Matsuoka R, Ochiya T. Maintaining good miRNAs in the body keeps the doctor away?: Perspectives on the relationship between food-derived natural products and microRNAs in relation to exosomes/extracellular vesicles. Mol Nutr Food Res. 2018 Jan;62(1). doi: 10.1002/mnfr.201700080. Epub 2017 Aug 15. Review. PubMed PMID: 28594130.
  31. Gailhouste L, Liew LC, Yasukawa K, Hagiwara K, Iwazaki N, Yamada Y, Hatada I, Ochiya T. Epigenetic Reprogramming of Human Hepatoma Cells: A Low-Cost Option for Drug Metabolism Assessment. Cell Mol Gastroenterol Hepatol. 2017 Nov 22;5(3):454-457.e1. doi: 10.1016/j.jcmgh.2017.11.006. eCollection 2018 Mar. PubMed PMID: 29675460; PubMed Central PMCID: PMC5904034.

2017年 論文業績


一覧
  1. Kadota T, Fujita Y, Yoshioka Y, Araya J, Kuwano K, Ochiya T. Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases. Mol Aspects Med. 2018 Apr;60:92-103. doi: 10.1016/j.mam.2017.11.005. Epub 2017 Nov 20. Review. PubMed PMID: 29146100.
  2. Shimagaki T, Yoshizumi T, Harimoto N, Yoshio S, Naito Y, Yamamoto Y, Ochiya T, Yoshida Y, Kanto T, Maehara Y. MicroRNA-125b expression and intrahepatic metastasis are predictors for early recurrence after hepatocellular carcinoma resection. Hepatol Res. 2018 Mar;48(4):313-321. doi: 10.1111/hepr.12990. Epub 2017 Dec 5. PubMed PMID: 28984009.
  3. Shiozawa K, Shuting J, Yoshioka Y, Ochiya T, Kondo T. Extracellular vesicle-encapsulated microRNA-761 enhances pazopanib resistance in synovial sarcoma. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1322-1327. doi: 10.1016/j.bbrc.2017.11.164. Epub 2017 Nov 27. PubMed PMID: 29191657.
  4. Otsuka K, Yamamoto Y, Matsuoka R, Ochiya T. Maintaining good miRNAs in the body keeps the doctor away?: Perspectives on the relationship between food-derived natural products and microRNAs in relation to exosomes/extracellular vesicles. Mol Nutr Food Res. 2018 Jan;62(1). doi: 10.1002/mnfr.201700080. Epub 2017 Aug 15. Review. PubMed PMID: 28594130.
  5. Yasui T, Yanagida T, Ito S, Konakade Y, Takeshita D, Naganawa T, Nagashima K, Shimada T, Kaji N, Nakamura Y, Thiodorus IA, He Y, Rahong S, Kanai M, Yukawa H, Ochiya T, Kawai T, Baba Y. Unveiling massive numbers of cancer-related urinary-microRNA candidates via nanowires. Sci Adv. 2017 Dec 15;3(12):e1701133. doi: 10.1126/sciadv.1701133. eCollection 2017 Dec. PubMed PMID: 29291244; PubMed Central PMCID: PMC5744465.
  6. Urabe F, Kosaka N, Yoshioka Y, Egawa S, Ochiya T. The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment. Clin Transl Med. 2017 Dec 13;6(1):45. doi: 10.1186/s40169-017-0176-z. Review. PubMed PMID: 29238879; PubMed Central PMCID: PMC5729179.
  7. Prieto-Vila M, Takahashi RU, Usuba W, Kohama I, Ochiya T. Drug Resistance Driven by Cancer Stem Cells and Their Niche. Int J Mol Sci. 2017 Dec 1;18(12). pii: E2574. doi: 10.3390/ijms18122574. Review. PubMed PMID: 29194401; PubMed Central PMCID: PMC5751177.
  8. Gailhouste L, Liew LC, Yasukawa K, Hagiwara K, Iwazaki N, Yamada Y, Hatada I, Ochiya T. Epigenetic Reprogramming of Human Hepatoma Cells: A Low-Cost Option for Drug Metabolism Assessment. Cell Mol Gastroenterol Hepatol. 2017 Nov 22;5(3):454-457.e1. doi: 10.1016/j.jcmgh.2017.11.006. eCollection 2018 Mar. PubMed PMID: 29675460; PubMed Central PMCID: PMC5904034.
  9. Hironaka-Mitsuhashi A, Matsuzaki J, Takahashi RU, Yoshida M, Nezu Y, Yamamoto Y, Shiino S, Kinoshita T, Ushijima T, Hiraoka N, Shimizu C, Tamura K, Ochiya T. A tissue microRNA signature that predicts the prognosis of breast cancer in young women. PLoS One. 2017 Nov 15;12(11):e0187638. doi: 10.1371/journal.pone.0187638. eCollection 2017. PubMed PMID: 29141042; PubMed Central PMCID: PMC5687766.
  10. Uotani K, Fujiwara T, Yoshida A, Iwata S, Morita T, Kiyono M, Yokoo S, Kunisada T, Takeda K, Hasei J, Numoto K, Nezu Y, Yonemoto T, Ishii T, Kawai A, Ochiya T, Ozaki T. Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma. Sci Rep. 2017 Nov 7;7(1):14634. doi: 10.1038/s41598-017-12660-5. PubMed PMID: 29116117; PubMed Central PMCID: PMC5676745.
  11. Yokoi A, Yoshioka Y, Hirakawa A, Yamamoto Y, Ishikawa M, Ikeda SI, Kato T, Niimi K, Kajiyama H, Kikkawa F, Ochiya T. A combination of circulating miRNAs for the early detection of ovarian cancer. Oncotarget. 2017 Sep 6;8(52):89811-89823. doi: 10.18632/oncotarget.20688. eCollection 2017 Oct 27. PubMed PMID: 29163790; PubMed Central PMCID: PMC5685711.
  12. Katsuda T, Ochiya T. Biological and clinical insights offered by chemically induced liver progenitors (CLiPs). Stem Cell Investig. 2017 Aug 21;4:68. doi: 10.21037/sci.2017.08.04. eCollection 2017. PubMed PMID: 28920061; PubMed Central PMCID: PMC5590016.
  13. Enomoto Y, Takagi R, Naito Y, Kiniwa T, Tanaka Y, Hamada-Tsutsumi S, Kawano M, Matsushita S, Ochiya T, Miyajima A. Identification of the novel 3′ UTR sequences of human IL-21 mRNA as potential targets of miRNAs. Sci Rep. 2017 Aug 10;7(1):7780. doi: 10.1038/s41598-017-07853-x. PubMed PMID: 28798470; PubMed Central PMCID: PMC5552845.
  14. Takano Y, Masuda T, Iinuma H, Yamaguchi R, Sato K, Tobo T, Hirata H, Kuroda Y, Nambara S, Hayashi N, Iguchi T, Ito S, Eguchi H, Ochiya T, Yanaga K, Miyano S, Mimori K. Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer. Oncotarget. 2017 Aug 7;8(45):78598-78613. doi: 10.18632/oncotarget.20009. eCollection 2017 Oct 3. PubMed PMID: 29108252; PubMed Central PMCID: PMC5667985.
  15. Kadota T, Yoshioka Y, Fujita Y, Kuwano K, Ochiya T. Extracellular vesicles in lung cancer-From bench to bedside. Semin Cell Dev Biol. 2017 Jul;67:39-47. doi: 10.1016/j.semcdb.2017.03.001. Epub 2017 Mar 4. Review. PubMed PMID: 28267596.
  16. Matsuzaki J, Ochiya T. Circulating microRNAs and extracellular vesicles as potential cancer biomarkers: a systematic review. Int J Clin Oncol. 2017 Jun;22(3):413-420. doi: 10.1007/s10147-017-1104-3. Epub 2017 Feb 27. Review. PubMed PMID: 28243946.
  17. Fujiwara T, Uotani K, Yoshida A, Morita T, Nezu Y, Kobayashi E, Yoshida A, Uehara T, Omori T, Sugiu K, Komatsubara T, Takeda K, Kunisada T, Kawamura M, Kawai A, Ochiya T, Ozaki T. Clinical significance of circulating miR-25-3p as a novel diagnostic and prognostic biomarker in osteosarcoma. Oncotarget. 2017 May 16;8(20):33375-33392. doi: 10.18632/oncotarget.16498. PubMed PMID: 28380419; PubMed Central PMCID: PMC5464875.
  18. Kawamura Y, Yamamoto Y, Sato TA, Ochiya T. Extracellular vesicles as trans-genomic agents: Emerging roles in disease and evolution. Cancer Sci. 2017 May;108(5):824-830. doi: 10.1111/cas.13222. Epub 2017 May 18. Review. PubMed PMID: 28256033; PubMed Central PMCID: PMC5448650.
  19. Takahashi RU, Prieto-Vila M, Hironaka A, Ochiya T. The role of extracellular vesicle microRNAs in cancer biology. Clin Chem Lab Med. 2017 May 1;55(5):648-656. doi: 10.1515/cclm-2016-0708. Review. PubMed PMID: 28231055.
  20. De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Sarkar P, Yoshioka Y, Kabasawa H, Iida T, Goto S, Toba K, Higuchi Y, Suzuki Y, Hara M, Kurosawa H, Narita I, Hirayama Y, Ochiya T, Saito A. Exocytosis-Mediated Urinary Full-Length Megalin Excretion Is Linked With the Pathogenesis of Diabetic Nephropathy. Diabetes. 2017 May;66(5):1391-1404. doi: 10.2337/db16-1031. Epub 2017 Mar 13. PubMed PMID: 28289043.
  21. Nishida-Aoki N, Ochiya T. [Multilateral Strategies Utilizing Exosomes for Cancer Therapy]. Gan To Kagaku Ryoho. 2017 May;44(5):367-372. Japanese. PubMed PMID: 28536329.
  22. Ichinohe N, Ishii M, Tanimizu N, Kon J, Yoshioka Y, Ochiya T, Mizuguchi T, Hirata K, Mitaka T. Transplantation of Thy1(+) Cells Accelerates Liver Regeneration by Enhancing the Growth of Small Hepatocyte-Like Progenitor Cells via IL17RB Signaling. Stem Cells. 2017 Apr;35(4):920-931. doi: 10.1002/stem.2548. Epub 2017 Jan 19. PubMed PMID: 27925343.
  23. Kanda Y, Osaki M, Onuma K, Sonoda A, Kobayashi M, Hamada J, Nicolson GL, Ochiya T, Okada F. Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases. Sci Rep. 2017 Mar 8;7:43567. doi: 10.1038/srep43567. PubMed PMID: 28272394; PubMed Central PMCID: PMC5341090.
  24. Yokoi A, Yoshioka Y, Yamamoto Y, Ishikawa M, Ikeda SI, Kato T, Kiyono T, Takeshita F, Kajiyama H, Kikkawa F, Ochiya T. Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer. Nat Commun. 2017 Mar 6;8:14470. doi: 10.1038/ncomms14470. PubMed PMID: 28262727; PubMed Central PMCID: PMC5343481.
  25. Narita M, Shimura E, Nagasawa A, Aiuchi T, Suda Y, Hamada Y, Ikegami D, Iwasawa C, Arakawa K, Igarashi K, Kuzumaki N, Yoshioka Y, Ochiya T, Takeshima H, Ushijima T, Narita M. Chronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200c. PLoS One. 2017 Feb 22;12(2):e0172115. doi: 10.1371/journal.pone.0172115. eCollection 2017. PubMed PMID: 28225782; PubMed Central PMCID: PMC5321411.
  26. Yamamoto Y, Ochiya T. Epithelial stem cell culture: modeling human disease and applications for regenerative medicine. Inflamm Regen. 2017 Feb 6;37:3. doi: 10.1186/s41232-017-0034-9. eCollection 2017. Review. PubMed PMID: 29259702;PubMed Central PMCID: PMC5725889.
  27. Naito Y, Yoshioka Y, Yamamoto Y, Ochiya T. How cancer cells dictate their microenvironment: present roles of extracellular vesicles. Cell Mol Life Sci. 2017 Feb;74(4):697-713. doi: 10.1007/s00018-016-2346-3. Epub 2016 Aug 31. Review. PubMed PMID: 27582126; PubMed Central PMCID: PMC5272899.
  28. Kawamata M, Katsuda T, Yamada Y, Ochiya T. In vitro reconstitution of breast cancer heterogeneity with multipotent cancer stem cells using small molecules. Biochem Biophys Res Commun. 2017 Jan 22;482(4):750-757. doi: 10.1016/j.bbrc.2016.11.106. Epub 2016 Nov 18. PubMed PMID: 27871860.
  29. Katsuda T, Kawamata M, Hagiwara K, Takahashi RU, Yamamoto Y, Camargo FD, Ochiya T. Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity. Cell Stem Cell. 2017 Jan 5;20(1):41-55. doi: 10.1016/j.stem.2016.10.007. Epub 2016 Nov 10. PubMed PMID: 27840021.
  30. Nishida-Aoki N, Tominaga N, Takeshita F, Sonoda H, Yoshioka Y, Ochiya T.Disruption of Circulating Extracellular Vesicles as a Novel Therapeutic Strategy against Cancer Metastasis. Mol Ther. 2017 Jan 4;25(1):181-191. doi: 10.1016/j.ymthe.2016.10.009. Epub 2017 Jan 4. PubMed PMID: 28129113; PubMed Central PMCID: PMC5363297.
  31. Liew LC, Katsuda T, Gailhouste L, Nakagama H, Ochiya T. Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in treating Alzheimer’s disease. Int Immunol. 2017 Jan 1;29(1):11-19. doi: 10.1093/intimm/dxx002. Review. PubMed PMID: 28184439.
  32. Kadota T, Yoshioka Y, Fujita Y, Ochiya T. Exosomes: toward clinical application. Nihon Yakurigaku Zasshi. 2017;149(3):119-122. doi: 10.1254/fpj.149.119. Review. Japanese. PubMed PMID: 28260741.
  33. Kocan B, Maziarz A, Tabarkiewicz J, Ochiya T, Banaś-Ząbczyk A. Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential. Stem Cells Int. 2017;2017:1653254. doi: 10.1155/2017/1653254. Epub 2017 Jul 5. Review. PubMed PMID: 28757877; PubMed Central PMCID: PMC5516761.
  34. Sanada T, Hirata Y, Naito Y, Yamamoto N, Kikkawa Y, Ishida Y, Yamasaki C, Tateno C, Ochiya T, Kohara M. Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles. Cell Mol Gastroenterol Hepatol. 2016 Oct 24;3(2):272-283. doi: 10.1016/j.jcmgh.2016.10.003. eCollection 2017 Mar. PubMed PMID: 28275693; PubMed Central PMCID: PMC5331779.

2016年 論文業績


一覧
  1. Naito Y, Yoshioka Y, Yamamoto Y, Ochiya T. How cancer cells dictate their microenvironment: present roles of extracellular vesicles. Cell Mol Life Sci. 2017 Feb;74(4):697-713. doi: 10.1007/s00018-016-2346-3. Epub 2016 Aug 31. Review. PubMed PMID: 27582126; PubMed Central PMCID: PMC5272899.
  2. Kawamata M, Katsuda T, Yamada Y, Ochiya T. In vitro reconstitution of breast cancer heterogeneity with multipotent cancer stem cells using small molecules. Biochem Biophys Res Commun. 2017 Jan 22;482(4):750-757. doi: 10.1016/j.bbrc.2016.11.106. Epub 2016 Nov 18. PubMed PMID: 27871860.
  3. Katsuda T, Kawamata M, Hagiwara K, Takahashi RU, Yamamoto Y, Camargo FD, Ochiya T. Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity. Cell Stem Cell. 2017 Jan 5;20(1):41-55. doi: 10.1016/j.stem.2016.10.007. Epub 2016 Nov 10. PubMed PMID: 27840021.
  4. Nezu Y, Hagiwara K, Yamamoto Y, Fujiwara T, Matsuo K, Yoshida A, Kawai A, Saito T, Ochiya T. miR-135b, a key regulator of malignancy, is linked to poor prognosis in human myxoid liposarcoma. Oncogene. 2016 Dec 1;35(48):6177-6188. doi: 10.1038/onc.2016.157. Epub 2016 May 9. PubMed PMID: 27157622; PubMed Central PMCID: PMC5143367.
  5. Akimoto M, Maruyama R, Takamaru H, Ochiya T, Takenaga K. Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment. Nat Commun. 2016 Nov 24;7:13589. doi: 10.1038/ncomms13589. PubMed PMID: 27882929; PubMed Central PMCID: PMC5123057.
  6. Kadota T, Fujita Y, Yoshioka Y, Araya J, Kuwano K, Ochiya T. Extracellular Vesicles in Chronic Obstructive Pulmonary Disease. Int J Mol Sci. 2016 Oct 27;17(11). pii: E1801. Review. PubMed PMID: 27801806; PubMed Central PMCID: PMC5133802.
  7. Sanada T, Hirata Y, Naito Y, Yamamoto N, Kikkawa Y, Ishida Y, Yamasaki C, Tateno C, Ochiya T, Kohara M. Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles. Cell Mol Gastroenterol Hepatol. 2016 Oct 24;3(2):272-283. doi: 10.1016/j.jcmgh.2016.10.003. eCollection 2017 Mar. PubMed PMID: 28275693; PubMed Central PMCID: PMC5331779.
  8. Ochiya T. Novel therapeutic strategies targeting liver cancer stem cells. Chin Clin Oncol. 2016 Oct;5(5):59. doi: 10.21037/cco.2016.03.10. Epub 2013 Mar 22. PubMed PMID: 27164858.
  9. Sasaki H, Yoshiike M, Nozawa S, Usuba W, Katsuoka Y, Aida K, Kitajima K, Kudo H, Hoshikawa M, Yoshioka Y, Kosaka N, Ochiya T, Chikaraishi T. Expression Level of Urinary MicroRNA-146a-5p Is Increased in Patients With Bladder Cancer and Decreased in Those After Transurethral Resection. Clin Genitourin Cancer. 2016 Oct;14(5):e493-e499. doi: 10.1016/j.clgc.2016.04.002. Epub 2016 Apr 9. PubMed PMID: 27157639.
  10. Makiguchi T, Yamada M, Yoshioka Y, Sugiura H, Koarai A, Chiba S, Fujino N, Tojo Y, Ota C, Kubo H, Kobayashi S, Yanai M, Shimura S, Ochiya T, Ichinose M. Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis. Respir Res. 2016 Sep 5;17(1):110. doi: 10.1186/s12931-016-0427-3. PubMed PMID: 27596748; PubMed Central PMCID: PMC5011900.
  11. Yoshimura A, Kawamata M, Yoshioka Y, Katsuda T, Kikuchi H, Nagai Y, Adachi N, Numakawa T, Kunugi H, Ochiya T, Tamai Y. Generation of a novel transgenic rat model for tracing extracellular vesicles in body fluids. Sci Rep. 2016 Aug 19;6:31172. doi: 10.1038/srep31172. PubMed PMID: 27539050; PubMed Central PMCID: PMC4990884.
  12. Junker K, Heinzelmann J, Beckham C, Ochiya T, Jenster G. Extracellular Vesicles and Their Role in Urologic Malignancies. Eur Urol. 2016 Aug;70(2):323-31. doi: 10.1016/j.eururo.2016.02.046. Epub 2016 Feb 28. Review. PubMed PMID: 26924769.
  13. Ueno M, Asada K, Toda M, Nagata K, Sotozono C, Kosaka N, Ochiya T, Kinoshita S, Hamuro J. Concomitant Evaluation of a Panel of Exosome Proteins and MiRs for Qualification of Cultured Human Corneal Endothelial Cells. Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4393-402. doi: 10.1167/iovs.16-19805. PubMed PMID: 27564521.
  14. Hori N, Narita M, Yamashita A, Horiuchi H, Hamada Y, Kondo T, Watanabe M, Igarashi K, Kawata M, Shibasaki M, Yamazaki M, Kuzumaki N, Inada E, Ochiya T, Iseki M, Mori T, Narita M. Changes in the expression of IL-6-Mediated MicroRNAs in the dorsal root ganglion under neuropathic pain in mice. Synapse. 2016 Aug;70(8):317-24. doi: 10.1002/syn.21902. Epub 2016 Jun 3. PubMed PMID: 26990296.
  15. Miura N, Kamita M, Kakuya T, Fujiwara Y, Tsuta K, Shiraishi H, Takeshita F, Ochiya T, Shoji H, Huang W, Ohe Y, Yamada T, Honda K. Efficacy of adjuvant chemotherapy for non-small cell lung cancer assessed by metastatic potential associated with ACTN4. Oncotarget. 2016 May 31;7(22):33165-78. doi: 10.18632/oncotarget.8890. PubMed PMID: 27121206; PubMed Central PMCID: PMC5078083.
  16. Hirahata M, Osaki M, Kanda Y, Sugimoto Y, Yoshioka Y, Kosaka N, Takeshita F, Fujiwara T, Kawai A, Ito H, Ochiya T, Okada F. PAI-1, a target gene of miR-143, regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma. Cancer Med. 2016 May;5(5):892-902. doi: 10.1002/cam4.651. Epub 2016 Jan 28. PubMed PMID: 26817521; PubMed Central PMCID: PMC4864819.
  17. Nojima M, Matsui T, Tamori A, Kubo S, Shirabe K, Kimura K, Shimada M, Utsunomiya T, Kondo Y, Iio E, Naito Y, Ochiya T, Tanaka Y. Global, cancer-specific microRNA cluster hypomethylation was functionally associated with the development of non-B non-C hepatocellular carcinoma. Mol Cancer. 2016 Apr 30;15(1):31. doi: 10.1186/s12943-016-0514-6. PubMed PMID: 27137948; PubMed Central PMCID: PMC4852433.
  18. Maziarz A, Kocan B, Bester M, Budzik S, Cholewa M, Ochiya T, Banas A. How electromagnetic fields can influence adult stem cells: positive and negative impacts. Stem Cell Res Ther. 2016 Apr 18;7(1):54. doi: 10.1186/s13287-016-0312-5. Review. PubMed PMID: 27086866; PubMed Central PMCID: PMC4834823.
  19. Fujita Y, Yoshioka Y, Ochiya T. Extracellular vesicle transfer of cancer pathogenic components. Cancer Sci. 2016 Apr;107(4):385-90. doi: 10.1111/cas.12896. Epub 2016 Mar 18. Review. PubMed PMID: 26797692; PubMed Central PMCID: PMC4832849.
  20. Kosaka N, Yoshioka Y, Fujita Y, Ochiya T. Versatile roles of extracellular vesicles in cancer. J Clin Invest. 2016 Apr 1;126(4):1163-72. doi: 10.1172/JCI81130. Epub 2016 Mar 14. Review. PubMed PMID: 26974161; PubMed Central PMCID: PMC4811151.
  21. Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T. Novel combination of serum microRNA for detecting breast cancer in the early stage. Cancer Sci. 2016 Mar;107(3):326-34. doi: 10.1111/cas.12880. Epub 2016 Mar 4. PubMed PMID: 26749252; PubMed Central PMCID: PMC4814263.
  22. Hayakawa Y, Kawada M, Nishikawa H, Ochiya T, Saya H, Seimiya H, Yao R, Hayashi M, Kai C, Matsuda A, Naoe T, Ohtsu A, Okazaki T, Saji H, Sata M, Sugimura H, Sugiyama Y, Toi M, Irimura T. Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs. Cancer Sci. 2016 Feb;107(2):189-202. doi: 10.1111/cas.12857. Review. PubMed PMID: 26919617; PubMed Central PMCID: PMC4768389.
  23. Ishiguro T, Sato A, Ohata H, Ikarashi Y, Takahashi RU, Ochiya T, Yoshida M, Tsuda H, Onda T, Kato T, Kasamatsu T, Enomoto T, Tanaka K, Nakagama H, Okamoto K. Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity. Cancer Res. 2016 Jan 1;76(1):150-60. doi: 10.1158/0008-5472.CAN-15-0361. Epub 2015 Dec 15. PubMed PMID: 26669863.
  24. Kubota D, Kosaka N, Fujiwara T, Yoshida A, Arai Y, Qiao Z, Takeshita F, Ochiya T, Kawai A, Kondo T. miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma. Sarcoma. 2016;2016:1390571. Epub 2016 Nov 21. PubMed PMID: 27990096; PubMed Central PMCID: PMC5136640.
  25. Koizume S, Ito S, Yoshioka Y, Kanayama T, Nakamura Y, Yoshihara M, Yamada R, Ochiya T, Ruf W, Miyagi E, Hirahara F, Miyagi Y. High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors. Thromb Haemost. 2016 Jan;115(2):299-310. doi: 10.1160/TH15-03-0213. Epub 2015 Oct 8. PubMed PMID: 26446354.
  26. Itami S, Eguchi Y, Mizutani T, Aoki E, Ohgi T, Kuroda M, Ochiya T, Kato N, Suzuki HI, Kawada N, Murakami Y. Control of HCV Replication With iMIRs, a Novel Anti-RNAi Agent. Mol Ther Nucleic Acids. 2015;4:e219. doi: 10.1038/mtna.2014.71. Epub 2016 Dec 6. PubMed PMID: 28110745; PubMed Central PMCID: PMC4345303.

2015年 論文業績


一覧
  1. Akagi T, Kato K, Kobayashi M, Kosaka N, Ochiya T, Ichiki T. On-chip immunoelectrophoresis of extracellular vesicles released from human breast cancer cells. PLoS One, 10:e0123603, 2015
  2. Fujita T, Chiwaki F, Takahashi RU, Aoyagi K, Yanagihara K, Nishimura T, Tamaoki M, Komatsu M, Komatsuzaki R, Matsusaki K, Ichikawa H, Sakamoto H, Yamada Y, Fukagawa T, Katai H, Konno H, Ochiya T, Yoshida T, Sasaki H. Identification and Characterization of CXCR4-Positive Gastric Cancer Stem Cells. PLoS One, 10:e0130808, 2015
  3. Fujita Y, Araya J, Ito S, Kobayashi K, Kosaka N, Yoshioka Y, Kadota T, Hara H, Kuwano K, Ochiya Takahir. Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis. J Extracell Vesicles, 4:28388, 2015
  4. Fujita Y, Kosaka N, Araya J, Kuwano K, Ochiya T. Extracellular vesicles in lung microenvironment and pathogenesis. Trends Mol Med, 21:533-542, 2015
  5. Fujita Y, Kuwano K, Ochiya T. Development of small RNA delivery systems for lung cancer therapy. Int J Mol Sci, 16:5254-5270, 2015
  6. Fujita Y, Yagishita S, Hagiwara K, Yoshioka Y, Kosaka N, Takeshita F, Fujiwara T, Tsuta K, Nokihara H, Tamura T, Asamura H, Kawaishi M, Kuwano K, Ochiya T. The clinical relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer. Mol Ther, 23:717-727, 2015
  7. Fujita Y, Yagishita S, Takeshita F, Yamamoto Y, Kuwano K, Ochiya T. Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer. Oncotarget, 6:3335-3345, 2015
  8. Hagiwara K, Gailhouste L, Yasukawa K, Kosaka N, Ochiya T. A robust screening method for dietary agents that activate tumour-suppressor microRNAs. Sci Rep, 5:14697, 2015
  9. Hagiwara K, Katsuda T, Gailhouste L, Kosaka N, Ochiya T. Commitment of Annexin A2 in recruitment of microRNAs into extracellular vesicles. FEBS Lett, 289:4071-4078, 2015
  10. Ishikawa T, Kobayashi M, Yanagi S, Kato C, Takashima R, Kobayashi E, Hagiwara K, Ochiya T. Human Induced Hepatic Lineage-Oriented Stem Cells: Autonomous Specification of Human iPS Cells toward Hepatocyte-Like Cells without Any Exogenous Differentiation Factors. PLoS One, 10:e0123193, 2015
  11. Izumi H, Tsuda M, Sato Y, Kosaka N, Ochiya T, Iwamoto H, Namba K, Takeda Y. Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages. J Dairy Sci, 98:2920-2933, 2015
  12. Katsuda T, Ochiya T. Molecular signatures of mesenchymal stem cell-derived extracellular vesicle-mediated tissue repair. Stem Cell Res Ther, 6:212, 2015
  13. Katsuda T, Oki K, Ochiya T. Potential application of extracellular vesicles of human adipose tissue-derived mesenchymal stem cells in Alzheimer’s disease therapeutics. Methods Mol Biol, 1212:171-181, 2015
  14. Kawaharada K, Kawamata M, Ochiya T. Rat embryonic stem cells create new era in development of genetically manipulated rat models. World J Stem Cells, 7:1054-1063, 2015
  15. Kosaka T, Davydova J, Ono HA, Akiyama H, Hirai SI, Ohno S, Takeshita F, Aoki K, Ochiya T, Yamamoto M, Kunisaki C, Endo I. Imaging and antitumoral effect of a cyclo-oxygenase 2-specific replicative adenovirus for small metastatic gastric cancer lesions. Anticancer Res, 35:5201-5210, 2015
  16. Lener T, Gimona M, Aigner L, Borger V, Buzas E, Camussi G, Chaput N, Chatterjee D, Court FA, Del Portillo HA, O’Driscoll L, Fais S, Falcon-Perez JM, Felderhoff-Mueser U, Fraile L, Gho YS, Gorgens A, Gupta RC, Hendrix A, Hermann DM, Hill AF, Hochberg F, Horn PA, de Kleijn D, Kordelas L, Kramer BW, Kramer-Albers EM, Laner-Plamberger S, Laitinen S, Leonardi T, Lorenowicz MJ, Lim SK, Lotvall J, Maguire CA, Marcilla A, Nazarenko I, Ochiya T, Patel T, Pedersen S, Pocsfalvi G, Pluchino S, Quesenberry P, Reischl IG, Rivera FJ, Sanzenbacher R, Schallmoser K, Slaper-Cortenbach I, Strunk D, Tonn T, Vader P, van Balkom BWM, Wauben M, Andaloussi SE, Thery C, Rohde E, Giebel B. Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper. J Extracell Vesicles, 4:30087, 2015
  17. Matsumura T, Sugimachi K, Iinuma H, Takahashi Y, Kurashige J, Sawada G, Ueda M, Uchi R, Ueo H, Takano Y, Shinden Y, Eguchi H, Yamamoto H, Doki Y, Mori M, Ochiya T, Mimori K. Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer. Br J Cancer, 113:275-281, 2015
  18. Murakami Y, Kubo S, Tamori A, Itami S, Kawamura E, Iwaisako K, Ikeda K, Kawada N, Ochiya T, Taguchi YH. Comprehensive analysis of transcriptome and metabolome analysis in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma. Sci Rep, 5:16294, 2015
  19. Naito Y, Tanaka Y, Ochiya T. microRNAs and Hepatitis B. Adv Exp Med Biol, 888:389-399, 2015
  20. Nishida-Aoki N, Ochiya T. Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles. Cell Mol Life Sci, 72:1849-1861, 2015
  21. Ochiya T, Takenaga K, Asagiri M, Nakano K, Satoh H, Watanabe T, Imajoh-Ohmi S, Endo H. Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction. Mol Ther Methods Clin Dev, 2:15008, 2015
  22. Ono M, Tsuda H, Kobayashi T, Takeshita F, Takahashi RU, Tamura K, Akashi-Tanaka S, Moriya T, Yamasaki T, Kinoshita T, Yamamoto J, Fujiwara Y, Ochiya T. The expression and clinical significance of ribophorin II (RPN2) in human breast cancer. Pathol Int, 65:301-308, 2015
  23. Osaki M, Okada F, Ochiya T. miRNA therapy targeting cancer stem cells: a new paradigm for cancer treatment and prevention of tumor recurrence. Ther Deliv, 6:323-337, 2015
  24. Sugimachi K, Matsumura T, Hirata H, Uchi R, Ueda M, Ueo H, Shinden Y, Iguchi T, Eguchi H, Shirabe K, Ochiya T, Maehara Y, Mimori K. Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. Br J Cancer, 112:532-538, 2015
  25. Takahashi RU, Miyazaki H, Ochiya T. The roles of microRNAs in breast cancer. Cancers (Basel), 7:598-616, 2015
  26. Takahashi RU, Miyazaki H, Takeshita F, Yamamoto Y, Minoura K, Ono M, Kodaira M, Tamura K, Mori M, Ochiya T. Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1. Nat Commun, 6:7318, 2015
  27. Tokuhisa M, Ichikawa Y, Kosaka N, Ochiya T, Yashiro M, Hirakawa K, Kosaka T, Makino H, Akiyama H, Kunisaki C, Endo I. Exosomal miRNAs from peritoneum lavage fluid as potential prognostic biomarkers of peritoneal metastasis in gastric cancer. PLoS One, 10:e0130472, 2015
  28. Tominaga N, Katsuda T, Ochiya T. Micromanaging of tumor metastasis by extracellular vesicles. Semin Cell Dev Biol, 40:52-59, 2015
  29. Tominaga N, Kosaka N, Ono M, Katsuda T, Yoshioka Y, Tamura K, Lotvall J, Nakagama H, Ochiya T. Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier. Nat Commun, 6:6716, 2015
  30. Tominaga N, Yoshioka Y, Ochiya T. A novel platform for cancer therapy using extracellular vesicles. Adv Drug Deliv Rev, 95:50-55, 2015
  31. Urata YN, Takeshita F, Tanaka H, Ochiya T, Takimoto M. Targeted knockdown of the kinetochore protein D40/Knl-1 inhibits human cancer in a p53 status-independent manner. Sci Rep, 5:13676, 2015
  32. Yokoi A, Yoshioka Y, Ochiya T. Towards the realization of clinical extracellular vesicle diagnostics: challenges and opportunities. Expert Rev Mol Diagn, 15:1555-1566, 2015
  33. Yoshioka Y, Katsuda T, Ochiya T. Circulating microRNAs as hormones: intercellular and inter-organ conveyors of epigenetic information? EXS, 106:255-267, 2015

2014年 論文業績


一覧
  1. Chen AK, Sengupta P, Waki K, Van Engelenburg SB, Ochiya T, Ablan SD, Freed EO, Lippincott-Schwartz J. MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production. Proc Natl Acad Sci U S A, 111:E2676-E2683, 2014
  2. Fujita Y, Kuwano K, Ochiya T. Challenges and strategies for pulmonary delivery of microRNA-based therapeutics. In: Babashah S (ed), MicroRNAs: Key Regulators of Oncogenesis. Switzerland, Springer, pp 413-428, 2014
  3. Fujita Y, Kuwano K, Ochiya T. The potential role of MicroRNA-based therapy for lung cancer stem cells. In: Sarkar FH (ed), MicroRNA Targeted Cancer Therapy. Switzerland, Springer International Publishing, pp 83-98, 2014
  4. Fujita Y, Kuwano K, Ochiya T, Takeshita F. The impact of extracellular vesicle-encapsulated circulating microRNAs in lung cancer research. Biomed Res Int, 2014:486413, 2014
  5. Fujita Y, Yoshioka Y, Ito S, Araya J, Kuwano K, Ochiya T. Intercellular communication by extracellular vesicles and their microRNAs in asthma. Clin Ther, 36:873-881, 2014
  6. Fujiwara T, Katsuda T, Hagiwara K, Kosaka N, Yoshioka Y, Takahashi RU, Takeshita F, Kubota D, Kondo T, Ichikawa H, Yoshida A, Kobayashi E, Kawai Akira, Ozaki T, Ochiya T. Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells. Stem Cells, 32:959–973, 2014
  7. Fujiwara T, Kawai A, Nezu Y, Fujita Y, Kosaka N, Ozaki T, Ochiya T. Circulating microRNAs in sarcoma: potential biomarkers for diagnosis and targets for therapy. Chemotherapy, 3:1000123, 2014
  8. Fujiwara T, Kunisada T, Takeda K, Uotani K, Yoshida A, Ochiya T, Ozaki T. MicroRNAs in soft tissue sarcomas: overview of the accumulating evidence and importance as novel biomarkers. Biomed Res Int, 2014:592868, 2014
  9. Fujiwara T, Takahashi RU, Kosaka N, Nezu Y, Kawai A, Ozaki T, Ochiya T. RPN2 gene confers osteosarcoma cell malignant phenotypes and determines clinical prognosis. Mol Ther Nucleic Acids, 3:e189, 2014
  10. Hagiwara K, Ochiya T, Kosaka N. A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications. Drug Deliv Transl Res, 4:31-37, 2014
  11. Haldrup C, Kosaka N, Ochiya T, Borre M, Høyer S, Orntoft TF, Sorensen KD. Profiling of circulating microRNAs for prostate cancer biomarker discovery. Drug Deliv Transl Res, 4:19-30, 2014
  12. Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase M. Time-dependent expression profiles of microRNAs and mRNAs in rat milk whey. PLoS One, 9:e88843, 2014
  13. Katsuda T, Ikeda S, Yoshioka Y, Kosaka N, Kawamata M, Ochiya T. Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application. Biol Chem, 395:365-373, 2014
  14. Katsuda T, Kosaka N, Ochiya T. The roles of extracellular vesicles in cancer biology: toward the development of novel cancer biomarkers. Proteomics, 14:412-425, 2014
  15. Katsuda T, Kurata H, Tamai R, Banas A, Ishii T, Ishikawa S, Ochiya T. The in vivo evaluation of the therapeutic potential of human adipose tissue-derived mesenchymal stem cells for acute liver disease. Methods Mol Biol, 1213:57-67, 2014
  16. Kosaka N, Yoshioka Y, Tominaga N, Hagiwara K, Katsuda T, Ochiya T. Dark side of the exosome: the role of the exosome in cancer metastasis and targeting the exosome as a strategy for cancer therapy. Future Oncol, 10:671-681, 2014
  17. Kurata H, Tamai R, Katsuda T, Ishikawa S, Ishii T, Ochiya T. Adipose tissue-derived mesenchymal stem cells in regenerative medicine treatment for liver cirrhosis – focused on efficacy and safety in preclinical and clinical studies. JSM Regen Med, 2:1012, 2014
  18. Ochiya T, Takenaga K, Endo H. Silencing of S100A4, a metastasis-associated protein, in endothelial cells inhibits tumor angiogenesis and growth. Angiogenesis, 17:17-26, 2014
  19. Ono M, Kosaka N, Tominaga N, Yoshioka Y, Takeshita F, Takahashi RU, Yoshida M, Tsuda H, Tamura K, Ochiya T. Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. Sci Signal, 7:ra63, 2014
  20. Osaki M, Kosaka N, Okada F, Ochiya T. Circulating microRNAs in drug safety assessment for hepatic and cardiovascular toxicity: the latest biomarker frontier? Mol Diagn Ther, 18:121-126, 2014
  21. Otsuka K, Ochiya T. Genetic networks lead and follow tumor development: microRNA regulation of cell cycle and apoptosis in the p53 pathways. Biomed Res Int, 2014:749724, 2014
  22. Seino S, Takeshita F, Asari A, Masuda Y, Kunou M, Ochiya T. No influence of exogenous hyaluronan on the behavior of human cancer cells or endothelial cell capillary formation. J Food Sci, 79:T1469-T1475, 2014
  23. Takahashi RU, Miyazaki H, Ochiya T. The role of microRNAs in the regulation of cancer stem cells. Front Genet, 4:1-11, 2014
  24. Takahashi RU, Ochiya T. RPN2: a promising therapeutic target for breast cancer? J Stem Cells Res, Rev & Rep, 1:2, 2014
  25. Thirion M, Kanda T, Murakami Y, Ochiya T, Iizasa H. MicroRNAs and oncogenic human viruses. In: Babashah S (ed), MicroRNAs: Key Regulators of Oncogenesis. Switzerland, Springer, pp 155-182, 2014
  26. Tominaga N, Hagiwara K, Kosaka N, Honma K, Nakagama H, Ochiya T. RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy. Mol Cancer, 13:134, 2014
  27. Yoshioka Y, Kosaka N, Konishi Y, Ohta H, Okamoto H, Sonoda H, Nonaka R, Yamamoto H, Ishii H, Mori M, Furuta K, Nakajima T, Hayashi H, Sugisaki H, Higashimoto H, Kato T, Takeshita F, Ochiya T. Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen. Nat Commun, 5:3591, 2014

2013年 論文業績


一覧
  1. Fujita Y, Takeshita F, Kuwano K, Ochiya T. RNAi therapeutic platforms for lung diseases. Pharmaceuticals, 6:223-250, 2013
  2. Fujita Y, Takeshita F, Mizutani T, Ohgi T, Kuwano K, Ochiya T. A novel platform to enable inhaled naked RNAi medicine for lung cancer. Sci Rep, 3:3325, 2013
  3. Fujiwara T, Kawai A, Yoshida A, Ozaki T, Ochiya T. Cancer stem cells of sarcoma. In: Fujiwara T, Kawai A, Yoshida A, Ozaki T, Ochiya T (eds), Role of cancer stem cells in cancer biology and therapy. USA, CRC Press, pp 23-78, 2013
  4. Gailhouste L, Gomez-Santos L, Hagiwara K, Hatada I, Kitagawa N, Kawaharada K, Thirion M, Kosaka N, Takahashi RU, Shibata T, Miyajima A, Ochiya T. miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells. Hepatology, 58:1153-1165, 2013
  5. Gailhouste L, Gomez-Santos L, Ochiya T. Potential applications of miRNAs as diagnostic and prognostic markers in liver cancer. Front Biosci, 18:199-223, 2013
  6. Gailhouste L, Ochiya T. Cancer-related microRNAs and their role as tumor suppressors and oncogenes in hepatocellular carcinoma. Histol histopathol, 28:437-451, 2013
  7. Gailhouste L, Ochiya T. MicroRNAs: new tools to tackle liver cancer progression. Cancer Diagnostics, pp 12-14, 2013
  8. Hagiwara K, Gailhouste L, Kosaka N, Ochiya T. The emerging function of natural products as regulators of miRNAs in human diseases. In: Sahu SC (ed), microRNAs in Toxicology and Medicine. U.K., John Wiley & Sons, Ltd., pp 237-248, 2013
  9. Higashimoto M, Sakai Y, Takamura M, Usui S, Nasti A, Yoshida K, Seki A, Komura T, Honda M, Wada T, Furuichi K, Ochiya T, Kaneko S. Adipose tissue derived stromal stem cell therapy in murine ConA-derived hepatitis is dependent on myeloid-lineage and CD4+ T-cell suppression. Eur J Immunol, 43:2956-2968, 2013
  10. Hong J, He H, Bui P, Ryba-White B, Rumi MAK, Soares MJ, Dutta D, Paul S, Kawamata M, Ochiya T, Ying QL, Rajanahalli P, Weiss ML. A focused microarray for screening rat embryonic stem cell lines. Stem Cells Dev, 22:431-443, 2013
  11. Horii T, Morita S, Kimura M, Kobayashi R, Tamura D, Takahashi RU, Kimura H, Suetake I, Ohata H, Okamoto K, Tajima S, Ochiya T, Abe Y, Hatada I. Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system. PeerJ, 1:e230, 2013
  12. Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T. Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. J Clin Invest, 123:4627-4640, 2013
  13. Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase M. Purification of RNA from milk whey. Methods Mol Biol, 1024:191-201, 2013
  14. Kato K, Kobayashi M, Hanamura N, Akagi T, Kosaka N, Ochiya T, Ichiki T. Electrokinetic evaluation of individual exosomes by on-chip microcapillary electrophoresis with laser dark-field microscopy. Jpn J Appl Phys, 52:06GK10-1-06GK10, 2013
  15. Katsuda T, Kojima N, Ochiya T, Sakai Y. Biliary epithelial cells play an essential role in the reconstruction of hepatic tissue with a functional bile ductular network. Tissue Eng Part A, 19:2402-2411, 2013
  16. Katsuda T, Kosaka N, Takeshita F, Ochiya T. The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteomics, 13:1637-1653, 2013
  17. Katsuda T, Teratani T, Chowdhury MM, Ochiya T, Sakai Y. Hypoxia efficiently induces differentiation of mouse embryonic stem cells into endodermal and hepatic progenitor cells. Biochem Eng J, 74:95-101, 2013
  18. Katsuda T, Tsuchiya R, Kosaka N, Yoshioka Y, Takagaki K, Oki K, Takeshita F, Sakai Y, Kuroda M, Ochiya T. Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes. Sci Rep, 3:1197, 2013
  19. Kosaka N, Iguchi H, Hagiwara K, Yoshioka Y, Takeshita F, Ochiya T. Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J Biol Chem, 288:10849-10859, 2013
  20. Kosaka N, Takeshita F, Yoshioka Y, Hagiwara K, Katsuda T, Ono M, Ochiya T. Exosomal tumor-suppressive microRNAs as novel cancer therapy: “exocure” is another choice for cancer treatment. Adv Drug Deliv Rev, 65:376-382, 2013
  21. Kosaka N, Yoshioka Y, Hagiwara K, Tominaga N, Katsuda T, Ochiya T. Trash or treasure: extracellular microRNAs and cell-to-cell communication. Front Genet, 4:173, 2013
  22. Kosaka N, Yoshioka Y, Hagiwara K, Tominaga N, Ochiya T. Functional analysis of exosomal microRNA in cell-cell communication research. In: (ed), Circulating MicroRNAs – Methods and Protocols, Methods in Molecular Biology Volume 1024. Germany, Springer, pp 1-10, 2013
  23. Morita S, Horii T, Kimura M, Ochiya T, Tajima S, Hatada I. miR-29 represses the activities of DNA methyltransferases and DNA demethylases. Int J Mol Sci, 14:14647-14658, 2013
  24. Nakagawa SI, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M. Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection. PLoS One, 8:e59611, 2013
  25. Ochiya T, Lotvall J. Exosome as a novel shuttle for innovation. preface. Adv Drug Deliv Rev, 65:v, 2013
  26. Ohno S, Takanashi M, Sudo K, Ueda S, Ishikawa A, Matsuyama N, Fujita K, Mizutani T, Ohgi T, Ochiya T, Gotoh N, Kuroda M. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther, 21:185-191, 2013
  27. Seki A, Sakai Y, Komura T, Nasti A, Yoshida K, Higashimoto M, Honda M, Usui S, Takamura M, Takamura T, Ochiya T, Furuichi K, Wada T, Kaneko S. Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model. Hepatology, 58:1133-1142, 2013
  28. Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM. Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models. Adv Drug Deliv Rev, 65:383-390, 2013
  29. Takahashi RU, Takeshita F, Honma K, Ono M, Kato K, Ochiya T. Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β. Sci Rep, 3:2474, 2013
  30. Thirion M, Ochiya T. Extracellular microRNAs as potential biomarkers and therapeutic tools in cancer. In: Lopez-Camarillo C, Marchat LA (eds), MicroRNAs in Cancer. USA, CRC Press, pp 308-332, 2013
  31. Thirion M, Ochiya T. Roles of microRNAs in the hepatitis B virus infection and related diseases. Viruses, 5:2690-2703, 2013
  32. Uchino K, Ochiya T, Takeshita F. RNAi therapeutics and applications of microRNAs in cancer treatment. Jpn J Clin Oncol, 43:596-607, 2013
  33. Uchino K, Takeshita F, Takahashi RU, Kosaka N, Fujiwara K, Naruoka H, Sonoke S, Yano J, Sasaki H, Nozawa S, Yoshiike M, Kitajima K, Chikaraishi T, Ochiya T. Therapeutic Effects of MicroRNA-582-5p and -3p on the Inhibition of Bladder Cancer Progression. Mol Ther, 21:610-619, 2013
  34. Yoshioka Y, Konishi Y, Kosaka N, Katsuda T, Kato T, Ochiya T. Comparative marker analysis of extracellular vesicles in different human cancer types. J Extracell Vesicles, 2:20424, 2013

2012年 論文業績


一覧
  1.  Furuichi K, Shintani H, Sakai Y, Ochiya T, Matsushima K, Kaneko S, Wada T. Effects of adipose-derived mesenchymal cells on ischemia-reperfusion injury in kidney. Clin Exp Nephrol, 16:679-689, 2012
  2.  Gailhouste L. Isolation and purification method of mouse fetal hepatoblasts. Methods Mol Biol, 826:33-47, 2012
  3.  Goda T, Masuno K, Nishida J, Kosaka N, Ochiya T, Matsumoto A, Miyahara Y. A label-free electrical detection of exosomal microRNAs using microelectrode array. Chem Commun, 48:11942-11944, 2012
  4.  Hagiwara K, Kosaka N, Yoshioka Y, Takahashi RU, Takeshita F, Ochiya T. Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity. Sci Rep, 2:314, 2012
  5.  Hamasaki T, Suzuki H, Shirohzu H, Matsumoto T, D’Alessandro-Gabazza CN, Gil-Bernabe P, Boveda-Ruiz D, Naito M, Kobayashi T, Toda M, Mizutani T, Taguchi O, Morser J, Eguchi Y, Kuroda M, Ochiya T, Hayashi H, Gabazza EC, Ohgi T. Efficacy of a novel class of RNA interference therapeutic agents. PLoS One, 7:e42655, 2012
  6.  Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen YR, Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A. Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A, 109:4263-4268, 2012
  7.  Ishikawa T, Banas A, Teratani T, Iwaguro H, Ochiya T. Regenerative cells for transplantation in hepatic failure. Cell Transplant, 21:387-399, 2012
  8.  Ishikawa T, Hagiwara K, Ochiya T. Generaton and Hepatic Differentiation of Human iPS Cells. Methods Mol Biol, 826:103-114, 2012
  9.  Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase M. Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions. J Dairy Sci, 95:4831-4841, 2012
  10. 74. Katsuda T, Sakai Y, Ochiya T. Induced pluripotent stem cell-derived hepatocytes as an alternative to human adult hepatocytes. J Stem Cells, 7:1-17, 2012
  11. 75. Katsuda T, Sakai Y, Ochiya T. Induced pluripotent stem cell-derived hepatocytes as an alternative to human adult hepatocytes. J Stem Cells, 7:1-17, 2012
  12.  Kawamata M, Ochiya T. Two distinct knockout approaches highlight a critical role for p53 in rat development. Sci Rep, 2:945, 2012
  13.  Kobayashi S, Yamada-Okabe H, Suzuki M, Natori O, Kato A, Matsubara K, Jau Chen Y, Yamazaki M, Funahashi S, Yoshida K, Hashimoto E, Watanabe Y, Mutoh H, Ashihara M, Kato C, Watanabe T, Yoshikubo T, Tamaoki N, Ochiya T, Kuroda M, Levine AJ, Yamazaki T. LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. Stem Cells, 30:2631-2644, 2012
  14.  Kosaka N, Iguchi H, Yoshioka Y, Hagiwara K, Takeshita F, Ochiya T. Competitive interactions of cancer cells and normal cells via secretory microRNAs. J Biol Chem, 287:1397-1405, 2012
  15.  Kosaka N, Ochiya T. Unraveling the mystery of cancer by secretory microRNA: horizontal microRNA transfer between living cells. Front Genet, 2:97, 2012
  16.  Morita S, Takahashi RU, Yamashita R, Toyoda A, Horii T, Kimura M, Fujiyama A, Nakai K, Tajima S, Matoba R, Ochiya T, Hatada I. Genome-wide analysis of DNA methylation and Expression of microRNAs in breast cancer cells. Int J Mol Sci, 13:8259-8272, 2012
  17.  Murakami Y, Toyoda H, Tanahashi T, Tanaka J, Kumada T, Yoshioka Y, Kosaka N, Ochiya T, Taguchi YH. Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease. PLoS One, 7:e48366, 2012
  18. 82. Ochiya T. RNA interference. In: Schwab M (ed), Encyclopedia of Cancer, 3rd edition. Germany, Springer, 2012
  19. 83. Ochiya T. Secretory microRNAs by Exosomes as a versatile communication tool. Dent Med Res, 32:158-161, 2012
  20. 84. Ono M, Fujiwara Y, Ochiya T. Breast cancer stem cell: translating to the clinic. In: Hayat MA (ed), Stem Cells and Cancer Stem Cells, volume 4. Germany, Springer-Verlag, pp 249-257, 2012
  21.  Takeshita F, Takahashi RU, Onodera J, Ochiya T. In vivo imaging of oligonucleotide delivery. Methods Mol Biol, 872:243-253, 2012
  22.  Yoshioka Y, Kosaka N, Ochiya T, Kato T. Micromanaging iron homeostasis – Hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins. J Biol Chem, 287:34110-34119, 2012

2011年 論文業績


一覧
  1. Katsuda T, Sakai Y, Ochiya T. Induced pluripotent stem cell-derived hepatocytes as an alternative to human adult hepatocytes. In: Sullivan PJ, Mortensen EK (eds), Induced Stem Cells. USA, Nova Science Publishers, pp 75-103, 2011
  2. Kawamata M, Ochiya T. Gene-manipulated embryonic stem cells for rat transgenesis. Cell Mol Life Sci, 68:1911-1915, 2011
  3. Kawamata M, Ochiya T. Establishment of embryonic stem cells and generation of genetically modified rats. In: Craig A (ed), Methodological Advances in the Culture. Croatia, InTech, pp 383-396, 2011
  4. Mino K, Ozaki M, Nakanishi K, Haga S, Sato M, Kina M, Takahashi M, Takahashi N, Kataoka A, Yanagihara K, Ochiya T, Kamiyama T, Umezawa K, Todo S. Inhibition of nuclear factor-kappaB suppresses peritoneal dissemination of gastric cancer by blocking cancer cell adhesion. Cancer Sci, 102:1052-1058, 2011
  5. Murakami Y, Toyoda H, Tanaka M, Kuroda M, Harada Y, Matsuda F, Tajima A, Kosaka N, Ochiya T, Shimotohno K. The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PLoS One, 6:e16081, 2011
  6. Osaki M, Takeshita F, Sugimoto Y, Kosaka N, Yamamoto Y, Yoshioka Y, Kobayashi E, Yamada T, Kawai A, Inoue T, Ito H, Oshimura M, Ochiya T. MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. Mol Ther, 19:1123-1130, 2011
  7. Takahashi RU, Takeshita F, Fujiwara T, Ono M, Ochiya T. Cancer stem cells in breast cancer. Cancers, 3:1311-1328, 2011
  8. Watanabe H, Kominami Y, Gon R, Hayashi M, Nishiki M, Sasaki A, Shiraishi M, Ueda S, Ochiya T, Kamiya K. Trans-differentiation of a duodenal phenotype on duodenal transplantation of different normal tissues in F344 rats. Hiroshima J Med Sci, 60:1-6, 2011
  9. Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, Tamaki A, Matsunaga J, Takahashi RU, Takata T, Shimamoto A, Ochiya T, Tahara H. miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol, 193:409-424, 2011
  10. Yamamoto Y, Yoshioka Y, Minoura K, Takahashi RU, Takeshita F, Taya T, Horii R, Fukuoka Y, Kato T, Kosaka N, Ochiya T. An integrative genomic analysis revealed the relevance of microRNA and gene expression for drug-resistance in human breast cancer cells. Mol Cancer, 10:135, 2011

2010年 論文業績


一覧
  1. Adachi T, Kawakami E, Ishimaru N, Ochiya T, Hayashi Y, Ohuchi H, Tanihara M, Tanaka E, Noji S. Delivery of small interfering RNA with a synthetic collagen poly(Pro-Hyp-Gly) for gene silencing in vitro and in vivo. Dev Growth Differ, 52:693-699, 2010
  2. Chowdhury MM, Katsuda T, Montagne K, Kimura H, Kojima N, Akutsu H, Ochiya T, Fujii T, Sakai Y. Enhanced effects of secreted soluble factor preserve better pluripotent state of embryonic stem cell culture in a membrane-based compartmentalized micro-bioreactor. Biomed Microdevices, 12:1097-1105, 2010
  3. Gu SH, Xu WD, Xu L, Li XK, Ochiya T, Wang Y, Li JF, Gu YD, Xu JG. Regenerated host axons form synapses with neurons derived from neural stem cells transplanted into peripheral nerves. J Int Med Res, 38:1721-1729, 2010
  4. Iguchi H, Kosaka N, Ochiya T. Secretory microRNAs as a versatile communication tool. Commun Integr Biol, 3:478-481, 2010
  5. Iguchi H, Kosaka N, Ochiya T. Versatile applications of microRNA in anti-cancer drug discovery: from therapeutics to biomarkers. Curr Drug Discov Technol, 7:95-105, 2010
  6. Ishikawa T, Banas A, Hagiwara K, Iwaguro H, Ochiya T. Stem cells for hepatic regeneration: the role of adipose tissue derived mesenchymal stem cells. Curr Stem Cell Res Ther, 5:182-189, 2010
  7. Jazwa A, Kucharzewska P, Leja J, Zagorska A, Sierpniowska A, Stepniewski J, Kozakowska M, Taha H, Ochiya T, Derlacz R, Vahakangas E, Yla-Herttuala S, Jozkowicz A, Dulak J. Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice. Genet Vaccines Ther, 8:6, 2010
  8. Katsuda T, Teratani T, Ochiya T, Sakai Y. Transplantation of a fetal liver cell-loaded hyaluronic acid sponge onto the mesentery recovers a Wilson’s disease model rat. J Biochem, 148:281-288, 2010
  9. Kawamata M, Ochiya T. Establishment of embryonic stem cells from rat blastocysts. Methods Mol Biol, 597:169-177, 2010
  10. Kawamata M, Ochiya T. Generation of genetically modified rats from embryonic stem cells. PNAS, 107:14223-14228, 2010
  11. Kosaka N, Iguchi H, Ochiya T. Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci, 101:2087-2092, 2010
  12. Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem, 285:17442-17452, 2010
  13. Kosaka N, Izumi H, Sekine K, Ochiya T. microRNA as a new immune-regulatory agent in breast milk. Silence, 1:7, 2010
  14. Ochiya T, Yamamoto Y, Banas A. Commitment of stem cells into functional hepatocytes. Differentiation, 79:65-73, 2010
  15. Takeshita F, Patrawala L, Osaki M, Takahashi R, Yamamoto Y, Kosaka N, Kawamata M, Kelnar K, Bader AG, Brown D, Ochiya T. Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. Mol Ther, 18:181-187, 2010
  16. Tanooka H, Tatsumi K, Tsuji H, Noda Y, Katsube T, Ishii H, Ootsuyama A, Takeshita F, Ochiya T. Mutant mouse p53transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA. Cancer Gene Ther, 17:1-10, 2010

 

Kumazaki M, Shimomura I, Kiyono T, Ochiya T, Yamamoto Y. Cell-type specific
tumorigenesis with Ras oncogenes in human lung epithelial cells. Biochem Biophys
Res Commun. 2020 Feb 25. pii: S0006-291X(20)30394-6. doi:
10.1016/j.bbrc.2020.02.113. [Epub ahead of print] PubMed PMID: 32111352.

 

 

 

 

 

1: Noda-Narita S, Shimomura A, Tanabe Y, Kawauchi J, Matsuzaki J, Takizawa S,
Aoki Y, Shimizu C, Tamura K, Ochiya T. Peripheral neuropathy from paclitaxel:
risk prediction by serum microRNAs. BMJ Support Palliat Care. 2020 Jan 14. pii:
bmjspcare-2019-001900. doi: 10.1136/bmjspcare-2019-001900. [Epub ahead of print]
PubMed PMID: 31937590.

1: Noda-Narita S, Shimomura A, Tanabe Y, Kawauchi J, Matsuzaki J, Takizawa S,
Aoki Y, Shimizu C, Tamura K, Ochiya T. Peripheral neuropathy from paclitaxel:
risk prediction by serum microRNAs. BMJ Support Palliat Care. 2020 Jan 14. pii:
bmjspcare-2019-001900. doi: 10.1136/bmjspcare-2019-001900. [Epub ahead of print]
PubMed PMID: 31937590.